Iron-catalyzed Alkyne Aza-Cope Mannich cyclization: A Method for the Synthesis of 5-alkyl-1-tosyl-2,5-dihydro-1H-pyrrole-3-carbaldehyde

摘要

The pyrrolidine ring is widely distributed throughout Nature, e.g. in alkaloids and is an important scaffold for drug discovery, being the core of many pharmaceutically significant compounds. Their toxicity and halucinatory activities are well known, but probably more important are their antibiotic, antibacterial, antifungal and cytotoxic effects, since they offer the opportunities for the development of novel pharmacological agents.