Concise Synthesis of (3R, 4S)-3-Hydroxy-4-Methyl-#gamma#-Butyrolactone

摘要

A three-step sequence involving highly stereoselective deconjugation of ethyl (E)-2-pentenoate, osmylation, and resolution by lipase-catalyzed enzymatic acetylation allowed an extremely expenditious synthesis of (3R,4S)-3-hdyroxy-4-methyl-#gamma#-butyrolactone with 90% ee, from which (-)-blastmycinolactol and (+)-blastmycinone were synthesized.