SYNTHESES AND ANTICHOLINESTERASE ACTIVITIES OF NOVEL 3-AMINOCARBONYLMETHYLENE-3-METHYL-2,3-DIHYDROBENZOFURAN-5-YL CARBAMATES

摘要

Novel carbamates 4 and 5 were synthesized from starting material 5-hydroxy-3-methyl-3H-benzofuran-2-one,17.The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of 4 and 5 were determined against fresh human enzyme,are in the realm of clinically valuable compounds and are discussed.In addition,the reductive properties of the 2-carbonyl group of 3H-benzofuran-2-one,possessing an unsaturated substituted group in its 3 position (9,11 and 14),were studied.