SYNTHESIS AND CYTOTOXICITY ACTIVITY OF SOME NOVEL HYDRAZIDE, PYRAZOLE, ISOXAZOLE, PYRIMIDINE AND FUSED PYRAN-2-ONE DERIVATIVES

摘要

The reaction of 2-cyano-3-(dimethylamino)-N-((2-methoxynaphthalen-1-yl)methylene)acrylohydrazide (2) with some nitrogen nucleophiles, phenols and compounds, having an active methylene group to obtain polyfunctionally substituted azoles (3-5), azine (6), fused azines (7-10) and fused pyran-2-one derivatives (11-17). All the synthesized products were confirmed by elemental analysis, IR, H-1-NMR,13C-NMR and MS data. The antitumor evaluation of the newly synthesized products against four human tumor cells lines namely hepatocellular carcinoma (liver) HepG-2, colorectal carcinoma (colon) HCT-116, mammary gland (breast) MCF-7 and epidermoid carcinoma (larynx) Hep-2 was investigated. Compound 4 exhibited superior in vitro antitumor activity in the 3-cell lines assay.