Reaction of Peroxyl Radicals with Uracils in the Event of Inhibition of Isopropyl Alcohol Oxidation

摘要

A number of pyrimidine derivatives (6-methyl-uracil, 5-fluorouracil, 5-hydroxy-6-methyluracil) are pharmaceuticals exhibiting a wide spectrum of activity. The efficacy of pharmaceuticals as antioxidants is one of the main characteristics of their biological activity. However, the mechanism of inhibition of free-radical-induced chain oxidation by uracils has been poorly studied. The primary event of attack of poten-tial antioxidant molecule by peroxyl radical plays an important role in the mechanism of oxidation retardation because it affects further reaction course. It is known [1] that the free-radical oxidation of virtually equimolar amounts of 2,2'-azobis(2-methylpropion-amide) dihydrochloride and 5-methyluracil with atmospheric oxygen for 25 h at 313 K leads to the following products: