Direct medical care costs among pegylated interferon plus ribavirin-treated and untreated chronic hepatitis C patients.

摘要

BACKGROUND: Hepatitis C virus (HCV) is a common and expensive infectious disease. The current standard of care for HCV infection, pegylated interferon with ribavirin (PEG-RBV), is costly and has a significant adverse event profile. AIM: To quantify the direct economic burden of HCV infection and PEG-RBV treatment for HCV. METHODS: Using a large administrative claims database, we evaluated the medical and prescription drug costs of patients with HCV from 2002 to 2007. A cohort of patients with PEG-RBV was 1:1 propensity score-matched to a cohort of untreated HCV patients. Multivariate models adjusted for demographic and clinical characteristics in evaluating the effect of PEG-RBV treatment on direct medical expenditure. RESULTS: The matched analysis included 20,002 patients. PEG-RBV-treated patients had higher total direct medical costs (Dollars 28,547 vs. Dollars 21,752; P < 0.001), outpatient pharmacy costs (Dollars 17,419 vs. Dollars 2,900; P < 0.001), and outpatient physician visit costs (Dollars 894 vs. Dollars 787; P < 0.001), but lower inpatient costs (Dollars 3,942 vs. Dollars 9,543; P < 0.001) and emergency room costs (Dollars 366 vs. Dollars 505; P < 0.001). After multivariate adjustment, PEG-RBV use was associated with an additional Dollars 9,423 in total direct medical costs and an additional Dollars 12,244 in HCV-related total medical costs. CONCLUSION: Total HCV-related medical costs are higher for treated than untreated patients, driven mostly by higher outpatient pharmacy costs, which outweigh higher HCV-related inpatient costs incurred by untreated patients.