Synthesis and evaluation of phenytoin derivatives as anticonvulsant agents

摘要

2,5-Dioxo-4,4-diphenylimidazolidine-1-carboxylic acid (2) was reacted with methyl ester of different amino acids (1a-c) and substituted benzhydrols (3a-b) in pyridine and in the presence of N,N dicyclohexyl carbodiimide (DCC) to yield a series of the title compounds, methyl 2-(2,5-dioxo-4,4-diphenylimidazolidine-1-carboxamido) substituted propanoate (4a-c) and benzhydryl 2,5-dioxo-4,4-diphenyl imidazolidine-1-car-boxylate (5a-b).The structures of these compounds were established on the basis of their spectral (IR, ~1H-NMR) data. These newly synthesized derivatives of phenytoin were evaluated in terms of anticonvulsant activity.