Synthesis of Some New 1-Acylthiosemicarbazides and 1,2,4-Triazol-5-Thiones,and Their Analgesic and Anti-Inflammatory Activities

摘要

We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4-substituted-thiosemicarbazides and their corresponding cyclized 3-[2-(2-oxobenzothiazoline-3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione analogs in which position 4 of the triazole ring was substituted by cyclohexyl,methyl,allyl,phenyl,p-methylphenyl,p-methoxyphenyl,p-chlorophenyl,p-nitrophenyl,benzyl,and phenylethyl to screen their analgesic and anti-inflammatory activities as well as gastric ulceration potential in test animals.None of the compounds,except 5a,5e,and 5h,caused gastric lesions or bleeding.Compound 5g was found to have higher analgesic and anti-inflammatory activity among the synthesized compounds.