Can increased albumin excretion provide evidence of early renal and cardiovascular disease in adolescents with Type 1 diabetes?

摘要

Diabetic nephropathy (DN) and cardiovascular disease (CVD) are among the most common vascular complications of Type 1 diabetes (T1D) that negatively influence the long-term prognosis of young people with that condition [i]. Several studies have shown that premature atherosclerosis represents the main cause of morbidity and mortality in patients with T1D p]. In longitudinal cohorts of adults with T1D from the USA and Europe, the incidence of coronary events has been found to be around 16% after 10 years of diabetes duration, significantly contributing to mortality [2]. This is confirmed by data from the Diabetes UK cohort of 23,751 patients with T1D, where by the age of 20-39 years, the standardized mortality rate for coronary artery disease was increased tenfold in men and 40-fold in women [3].