Comparison of antibody kinetics following meningococcal serogroup C conjugate vaccine between healthy adults previously vaccinated with meningococcal A/C polysaccharide vaccine and vaccine-naive controls

摘要

Few data are available on the kinetics of meningococcal serogroup C-specific antibody production following meningococcal serogroup C conjugate (MCC) vaccination, particularly in those who have received prior meningococcal A/C polysaccharide (MACP) vaccination(s). Laboratory staff who had previously received either one dose (n = 35), two doses (n = 18) of MACP vaccine or who were naive to previous meningococcal vaccination (n = 42) were vaccinated with R ICC. Bloods were taken pre-vaccination. on the subsequent 4 days and on days 10 and 28. Serogroup C serum bactericidal antibody (SBA), and anti-serogroup C-specific IgG, IgM and IgA were measured. There were no significant differences between the groups who had received either 2 or 1 prior dose(s) of MACP, therefore, these results were combined. Up to day 4 there was no evidence of a significant increase or decrease in the median levels of SEA, IgG, IgM or IEA in either the naive: or MACP groups, although about 20% of individuals did have 4-fold SEA rises by day 4. By day 10 there were large significant increases in the levels of SEA, IgG, IgM and IgA with respective fold increases from pre-vaccination levels of 4.6, 1.9, 1.2 and 2.1 in the MACP group and 270. 13.4, 4.8 and 33.8 in the naive group. Further significant increases were seen between day 10 and 28 for SEA, IgG and IgM (naive group only). By day 18, 4-fold SEA rises had occurred in 63.50% of the MACP group and 97.6% of the nai:ve group. The SEA GMT on day 28 significantly differed between the naive and MACP groups with GMT 2.8-fold higher in the naive group (P=0.021). In conclusion, no decline in serogroup C-specific antibody levels was demonstrated immediately post-MCC vaccination whilst these levels had risen significantly by day 10. Putative protective SEA titres (greater than or equal to 8, 32 or 128) were observed by day 10 following MCC vaccination regardless of MACP history.