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MENINGOCOCCAL MENINGOCOCCAL POLYSACCHARIDE CONJUGATE THEREOF WITH AN IMMUNOLOGICAL PROTEIN VACCINE COMPRISING SUCH CONJUGATE
MENINGOCOCCAL MENINGOCOCCAL POLYSACCHARIDE CONJUGATE THEREOF WITH AN IMMUNOLOGICAL PROTEIN VACCINE COMPRISING SUCH CONJUGATE
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机译:脑膜炎球菌多糖与含有这种结合物的免疫蛋白疫苗共轭
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摘要
Neisseria meningitidis group B polysaccharide (GBMP) modified by having sialic acid residue N-acetyl groups replaced by N-acyl groups exhibits enhanced immuno response thereto. In addition, induction of antibodies which cross-react with unmodified group B meningococcal and E. coli K1 capsular polysaccharide and other tissue cells having a common epitope is minimized. Conjugation of the modified polysaccharides with a physiologically acceptable protein such as tetanus toxoid induces the production of specific protective antibodies with negligible levels of GBMP-cross reactive antibodies, to thereby afford protection against infections caused by group B meningococci and E. coli K1.
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