Distortion correction of EPI data using multimodal nonrigid registration with an anisotropic regularization

摘要

In this paper, a novel strategy for correcting both geometric and image intensity distortions of echo-planar imaging (EPI) MRI data is presented. To deal with small local distortions caused by rapid changes of the magnetic field, an improved multimodal registration framework using normalized mutual information (NMI) in combination with a multi-scale technique is presented to estimate a dense displacement field. To ensure the robustness of this high dimensional ill-posed inverse problem, a novel anisotropic regularization functional is used.