Identification of impaired fasting blood glucose and diabetes increases in healthy young adults after mentally demanding task

摘要

The aim of the study was to investigate the influence of human functional state (in relative functional rest, after the night rest on fasting and during active mental activity) on the measurement of capillary blood glucose level in the diagnosis of carbohydrate metabolism disorders to avoid overdiagnosis (or even underdiagnosis) of "impaired fasting glucose" and "diabetes." The study was conducted with the participation of 27 males aged 20-29 years. The measurement was carried out using the glucose monitoring system "Rightest GM100" (Bionime, Switzerland) with an accuracy of up to 0.1 mmol/l. The first four measurements of blood glucose were conducted on the participants on fasting, approximately 10-16 hours after meal. On the first (initial) measurement of blood glucose, volunteers were in a state of functional rest (after the night rest). In the dynamics of mental work, fasting blood glucose measurements were conducted three times, after 2, 4, and 6 hours from the beginning of the study. After 30 minutes following the 4th measurement, glucose tolerance test was conducted. During glucose tolerance test, blood glucose was measured three times, precisely after 30, 60 and 120 minutes following oral intake of water (200 mL)-glucose solution (75 g) for each participant. The results showed that the number of identified "impaired fasting glucose" or even "diabetes" basically depends on the functional state of the participants. In the state of relative functional rest, "impaired fasting glucose" was detected in only one participant. In course of mental work, in 13 blood samples out of 80 samples taken (16.3 ± 4.2%; p <0.001) glucose level exceeded the upper limit of normoglycemia and corresponded to the criterion of "impaired fasting glucose" (9 samples) or "diabetes" (4 samples) during mental work (37.0 ± 9.5%; p <0.001). However, the glucose tolerance test did not reveal diabetes or impaired glucose tolerance. This indicates that when determining the fasting plasma glucose, it is important to standardize other conditions to avoid the influence of hyperglycemic effects, such as mental activity on fasting.