A Stereoselective Total Synthesis of Decarestrictine I

摘要

A convergent and stereoselective total synthesis of decarestrictine I, a polyketide natural product, is described. Both acid and alcohol fragments were prepared from the readily available l-malic acid via Still-Gennari olefination and Sharpless asymmetric epoxidation. The Steglich esterification and ringclosing metathesis (RCM) are employed to combine both acid and alcohol fragments.