首页> 外文期刊>Head and neck: Journal for the sciences and specialities of the head and neck >Non-Hodgkin's lymphoma of the head and neck: a 30-year experience at the University of Florida.
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Non-Hodgkin's lymphoma of the head and neck: a 30-year experience at the University of Florida.

机译:头部和颈部非霍奇金淋巴瘤:在佛罗里达大学拥有30年的经验。

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BACKGROUND: Outcome in previously untreated patients with non-Hodgkin's lymphoma of the head and neck needed to be assessed. METHODS: A retrospective review was performed of 79 patients with stage I or II non-Hodgkin's lymphoma of the head and neck treated between 1964 and 1994 with radiotherapy (RT) or combined modality therapy (CMT) at the University of Florida. Freedom from relapse, cause-specific survival, and absolute survival were analyzed by the Kaplan-Meier method. Patterns of failure were defined, and the relationship between dose and infield recurrence was studied. Histology was classified as low grade or intermediate/high grade. RESULTS: At 10 years, absolute survival for patients with low-grade lymphoma treated with RT was 45%; absolute survival for patients with intermediate/high-grade lymphoma was 41% for those treated with RT and 57% for those who received CMT. Twenty-seven patients had a recurrence of lymphoma after initial treatment. Twenty patients (74%) had recurrences outside the radiation treatment field; 90% of these failures were in predictable sites that would be included in comprehensive lymphatic irradiation fields (Waldeyer's ring, mantle, and whole abdomen). No clear dose response was observed. Multivariate analysis showed that patients with tumors <5 cm in diameter had improved cause-specific survival, absolute survival, and freedom from relapse compared with patients with tumors > or = 5 cm in diameter. CONCLUSIONS: Patients with non-Hodgkin's lymphoma in the head and neck with tumors > or = 5 cm in diameter appear to have a worse prognosis than those with smaller tumors. The patterns of failure suggest that initial treatment with comprehensive lymphatic irradiation fields could potentially eliminate the majority of treatment failures.
机译:背景:先前未经治疗的头颈部非霍奇金淋巴瘤患者的结局需要评估。方法:回顾性分析了佛罗里达大学在1964年至1994年之间接受放疗(RT)或联合方式疗法(CMT)治疗的79例I或II期头颈部非霍奇金淋巴瘤患者。通过Kaplan-Meier方法分析了无复发,病因特异性生存和绝对生存。定义了失败的模式,并研究了剂量与内场复发之间的关系。组织学分为低等级或中/高等级。结果:在10岁时,接受RT治疗的低度淋巴瘤患者的绝对生存率为45%。接受RT治疗的中/高度淋巴瘤患者的绝对生存率为41%,接受CMT的患者的绝对生存率为57%。初次治疗后,有27例患者复发了淋巴瘤。 20例患者(74%)在放射治疗领域以外复发。这些失败的90%位于可预测的部位,这些部位将包括在全面的淋巴照射领域(Waldeyer环,地幔和整个腹部)中。没有观察到明确的剂量反应。多变量分析显示,与直径大于或等于5 cm的肿瘤患者相比,直径小于5 cm的患者具有更高的原因特异性生存率,绝对生存率和无复发的可能性。结论:头颈部非霍奇金淋巴瘤的肿瘤直径大于或等于5 cm的患者的预后似乎比肿瘤较小的患者差。失败的模式表明,使用全面的淋巴照射场进行初始治疗可以潜在地消除大多数治疗失败。

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