Osteoarthritis diagnosis using wear particle analysis technique: Investigation of correlation between particle and cartilage surface in walking process

摘要

Osteoarthritis (OA), the most prevalent form of arthritis, is a degenerative joint disease affecting millions of people worldwide. The overall aims of the project were: (i) to gain a better understanding of the wear processes occurring in human joints during a walking process, particularly in relation to osteoarthritic degeneration and (ii) to develop effective, minimally intrusive tools to assess OA activity and progression. Based on existing developments, this project, using three-dimensional numerical descriptors, further investigated correlation between the cartilage surface subjected and particle generated in the walking process. This is a critical step in developing and utilizing wear particle analysis techniques for OA assessment. With further study and development along with this study, it is possible to develop better diagnostic and prognostic procedures for clinic OA assessment using wear debris analysis techniques.