Cu,Pt,and Pd complexes of the 3-deoxy-1,2bis(thiosemicarbazone)derived from

摘要

3-Deoxy-D-erythro-hexos-2-ulose bis(thiosemicarbazone)(1) acts as a tetradentate ligand of the N_2S_2 type which forms stable coordination complexes with metal(II)cations. The Cu(II),Pt(II),and Pd(II)chelates(2,4,and 6,respectively)of 1 were synthesized and characterized by elemental analysis and NMR spectroscopy.The NMR spectra of the Pt complex (4)showed the coupling of H-1,C-2 of the bvis(thiosemicarbazone)with ~(195)Pt (33.7% naturally occurring),which supports the structure proposed for the chelate. The complexes 2,4,and 6 were acetylated to give the corresponding tri-O-acetyl derivatives3,5 and 7. Elimination of Cu(II)from 3 with hydrogen sulfide afforded 8,the tri-O-acetyl derivative of 1.Preliminary studies have shown antiviral activity of chelates 2,4,and 6 against poliovirus type 1.