Chemical structure and immunity activity of Liquiritia glycyrrhiza heteropolysaccharide in animal

摘要

Liquiritia glycyrrhiza heteropolysaccharide was extracted and analyzed using high-performance gel permeation chromatography (HPGPC) and Fourier transform infrared spectroscopy (FTIR). HPGPC showed that the weight-average molecular weight (Mw) of L. glycyrrhiza heteropolysaccharide was 2.936 x 10~5 Da. A typical infrared spectrum of L. glycyrrhiza heteropolysaccharide showed strong absorbances at about 3282, 2921, 1608,1410 and 990 cm~(-1) and small ones at about 2853,1708, 1515, 1280, 1241, and 1103 cm~(-1). Ovarian cancer is a cancerous growth arising from different parts of the ovary. This study was designed to determine the effect of L glycyrrhiza heteropolysaccharide on immunity function in animal suffering from ovarian cancer. In the in vivo assay, model control animals displayed a decrease in immunity activities. After 30 days of treatment, L glycyrrhiza heteropolysaccharide-treated group showed a marked increase in immunity indexes (spleen and thymus index, IgA, IgG, IgM, IL-2, IFN-α and TNF-α levels) in comparison with the model control group. It can be concluded that L. glycyrrhiza heteropolysaccharide may improve immunity function in animal suffering from ovarian cancer.