Inhibition of alpha-glucosidase by polysaccharides from the fruit hull of Camellia oleifera Abel

摘要

We isolated and purified polysaccharides from the Camellia oleifera Abel. fruit hull and studied its hypoglycemic potential. Our results revealed six polysaccharides (CFPA-1-5 & CFPB) from the aqueous extract from the defatted C. oleifera fruit hull. Purified polysaccharides (purity >90%) were investigated for the inhibition of alpha-glucosidase activity in vitro. Two polysaccharides, CFPB and CFPA-3 were present in high concentration in the fruit hull and showed a dose-dependent inhibition of alpha-glucosidase activity, with IC50 concentrations of 11.80 and 10.95 mu g/mL, respectively. This result suggests that polysaccharides( CFP) extracted from the fruit hull of C. oleifera may have potential as functional foods with featuring a hypoglycemic effect. (C) 2014 Elsevier Ltd. All rights reserved.