Elevated Ca~(2+) influx-inducing activity toward mast cells inpretransfusion sera from patients who developedtransfusion-related adverse reactions

摘要

BACKGROUND: Type I allergic reactions such as urticaria-like manifestations constitute a large percentage of transfusion-related adverse events. Along with donor factors, patient factors might be involved in these reactions. Sera from some patients with chronic idiopathic urticaria show histamine-releasing activity (HRA). Sera from patients who develop Type I allergic reaction might possess HRA.