Severe haemolysis due to passenger lymphocyte syndrome after an ABO mismatched bowel transplant--a case report.

摘要

Passenger lymphocyte syndrome (PLS) is a subtype of graft vs host disease (GvHD) in which donor lymphocytes, transferred in the graft, produce antibodies to the recipient red cell antigens causing haemolysis. It occurs in both solid organ and stem cell transplants and is usually caused by antibodies to the ABO system. However, antibodies to other red cell systems, such as Rh (commonly), Kell, Kidd and Duffy (more rarely), have been described (Leo et al., 2000; Seltsam et al, 2001; Shortt et al., 2008), and tend to occur only if the donor has been previously sensitised through pregnancy or transfusion (Audet et al, 2008).