Does the fat cell have something to say to the platelet about keeping thrombosis in check in diabetes?

摘要

Diabetes mellitus, especially type 2 diabetes, is associated with accelerated atherosclerosis, resulting in an increased risk of myocardial infarction, stroke, and peripheral vascular disease. Patients with type 2 diabetes show multiple pathophysio-logic abnormalities, including a proinflammatory state, increased production of highly reactive oxidation products, dyslipidemia, abnormally functioning endothe-lium, aberrant cellular signal transduction, glycation of structural proteins, and abnormal platelet function. Atherosclerosis remains the most common cause of morbidity and mortality faced by these patients over a lifetime, and the management of layers of cardiovascular risk remains a major theme in diabetes treatment Therapies that lower glucose, blood pressure, lipids, body weight, and platelet hyper-activity address these risk factors, but atherosclerosis remains a ruthless adversary.