One of the pivotal diagnostic distinctions in psychiatry is between bipolar disorder and schizophrenia. Manic depressive psychosis was distinguished from psychosis in general in the 19th century and, following Kraepelin's work in the early 20th century, schizophrenia was differentiated in terms of its phenomenology and natural history. Although this clinical com-partmentalization of psychosis has been useful and enduring, there is increasing evidence that under the hood of the classically different phenotypes there may be more in common between bipolar disorder and schizophrenia than a strict Kraepelinian dichotomy would predict (1).
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