Rebuttal from Eduard Guasch and Stanley Nattel

摘要

In their interesting article, Ruiz et al. (2013) raise a number of points in disputing our contention that excess long-term exercise training can be harmful. First, they question the relevance of animal models. Our animal work, which exposed cardiac risks of high-level exercise training and defined underlying mechanisms, showed cardiac remodelling very similar to changes seen in man (Benito et al. 2011; Guasch et al. 2013). Our rat model roughly replicates running 11 km in one hour, 5 days a week, for 10 years (Guasch et al. 2013), well within the range of human high-intensity training. Our findings of atrial/right-ventricular dilatation and myo-cardial fibrosis are well supported by clinical data (O'Keefe et al. 2012). Ruiz et al.