Intricate vascular architecture revealed after removing the scaffolding: PSD95 crucial for vascular Kv1 function.

摘要

Post-synaptic density protein 95 (PSD95) is a key component of the complex signalling hierarchy in post-synaptic neuronal membranes. In neurones it is highly abundant and combines with an array of molecules including G-protein-coupled receptors, NO synthase, guanine nucleotide exchange factors, tyrosine kinases, anchoring proteins and motor proteins through separate PDZ, Src homology and guanylate kinase-like domains (Kim & Sheng, 2004). This role as a multi-factorial scaffold, integrating a myriad of signals, is fundamental for effective neuro-transmission and the synaptic plasticity inherent to memory and learning. In fact it could be said that this protein Cassanova, intimate and promiscuous, defines neuronal activity with its removal, leading to aberrant neuronal transmission.