A brighter side of ROS revealed by selective activation of beta-adrenergic receptor subtypes.

摘要

Because of the high metabolic demands on the heart, oxidative phosphorylation predominates over the less efficient process of anaerobic glycolysis for energy production. Under basal conditions, ~10% of the body's total oxygen supply is consumed by the heart (O'Rourke et al. 2005). This already staggering requirement rapidly increases during stress. Hence, oxygen bioavailability is a critical determinant of cardiomyocyte function and survival in health and disease. In this issue of The Journal of Physiology, Li et al.