We often hear how problems associated with alcohol abuse represent a massive economic and public health burden. Yet despite a concerted effort to identify new and effective pharmacotherapeutics, the drug treatment options available to treat alcohol disorders have progressed little over the past few decades. This is not to say there has been no progress in our understanding of how alcohol affects brain chemistry and behavior. On the contrary, there have been major insights into the neuropharma-cology of excessive alcohol drinking, revealing key roles and potential targets amongst various neuropeptides and neurotransmitters (1). In a report published in this issue of Biological Psychiatry, Nam ef al. (2) offer some potential new leads.
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机译：我们经常听到与酗酒有关的问题如何代表巨大的经济和公共卫生负担。然而，尽管人们为找到新的有效的药物治疗方法作出了共同努力，但过去几十年来，用于治疗酒精中毒的药物治疗方案进展甚微。这并不是说我们对酒精如何影响大脑化学和行为的理解没有任何进展。相反，对过量饮酒的神经药理学已有重要见解，揭示了各种神经肽和神经递质中的关键作用和潜在靶标（1）。 Nam ef al。在本期《生物精神病学》发表的一份报告中。 （2）提供一些潜在的新线索。
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