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Age-related changes of claudin expression in mouse liver, kidney, and pancreas

机译:小鼠肝脏,肾脏和胰腺中claudin表达的年龄相关变化

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Tight junctions (TJs) play crucial roles in tissue homeostasis and inflammation through their roles in the control of paracellular transport and barrier function. There is evidence that these functions are compromised in older organisms, but the exact mechanisms leading to TJ deterioration are not well understood. Claudin proteins are a family of membrane proteins that constitute the structural barrier elements of TJs and therefore play a major role in their formation and function. Using immunohistochemistry and immunoblotting, we have studied the expression of six different claudin proteins (claudin-1, -2, -3, -4, -5, and -7) in three tissues (liver, kidney, and pancreas) of aging male and female mice. In general, we find an age-dependent decrease in the expression of several claudin proteins in all three tissues observed, although the exact changes are tissue specific. Our findings provide a possible basis for the decrease in tissue barrier function in older organisms.
机译:紧密连接(TJ)通过控制细胞旁运输和屏障功能而在组织稳态和炎症中起关键作用。有证据表明,这些功能在较旧的生物体中受到损害,但是导致TJ恶化的确切机制尚不清楚。 Claudin蛋白是膜蛋白家族,构成TJ的结构屏障元件,因此在其形成和功能中起主要作用。使用免疫组织化学和免疫印迹,我们研究了衰老男性的三个组织(肝,肾和胰腺)中六种不同claudin蛋白(claudin-1,-2,-3,-4,-5和-7)的表达和雌性小鼠。通常,尽管确切的变化是组织特异性的,但我们发现在所观察到的所有三个组织中几种claudin蛋白的表达均随年龄而下降。我们的发现为老年生物体组织屏障功能的降低提供了可能的基础。

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