Implanted Muscle-Derived Stem Cells Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes, but Their Repair Capacity Is Impaired by Their Prior Exposure to the Diabetic Milieu

Kovanecz Istvan; Vernet Dolores; Masouminia Maryam; Gelfand Robert; Loni Leila; Aboagye James; Tsao James; Rajfer Jacob; Gonzalez-Cadavid Nestor F.

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Implanted Muscle-Derived Stem Cells Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes, but Their Repair Capacity Is Impaired by Their Prior Exposure to the Diabetic Milieu

机译：植入的肌肉衍生干细胞可改善2型糖尿病大鼠模型的勃起功能障碍，但其修复能力会因其先前暴露于糖尿病的环境而受损。

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Introduction: Muscle-derived stem cells (MDSCs) and other SCs implanted into the penile corpora cavernosa ameliorate erectile dysfunction in type 1 diabetic rat models by replenishing lost corporal smooth muscle cells (SMCs) and decreasing fibrosis. However, there are no conclusive data from models of type 2 diabetes (T2D) and obesity.

机译：简介：将肌肉衍生的干细胞（MDSC）和其他SC植入到1型糖尿病大鼠模型的阴茎海绵体中，可通过补充失去的身体平滑肌细胞（SMC）和减少纤维化来改善勃起功能障碍。但是，没有2型糖尿病（T2D）和肥胖症模型的确凿数据。

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《The journal of sexual medicine》 |2016年第5期|共12页
作者
Kovanecz Istvan; Vernet Dolores; Masouminia Maryam; Gelfand Robert; Loni Leila; Aboagye James; Tsao James; Rajfer Jacob; Gonzalez-Cadavid Nestor F.;
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正文语种 eng
中图分类性卫生;
关键词
Corpora Cavernosa; Corporal Veno-Occlusive Dysfunction; Diabetes; Dyslipidemia; Fibrosis; Hyperglycemia; Myostatin; Obesity; Smooth Muscle; Stem Cell Damage;

机译：海绵体;体腔闭塞性功能障碍;糖尿病;血脂异常;纤维化;高血糖;肌生长抑制素;肥胖症;平滑肌;干细胞损伤;

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1. Erratum to “Implanted Muscle-Derived Stem Cells Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes, but Their Repair Capacity is Impaired by Their Prior Exposure to the Diabetic Milieu” [J] . The journal of sexual medicine . 2017,第1期

机译：错误的“植入肌肉衍生的干细胞改善2型糖尿病大鼠模型中的勃起功能障碍，但它们的修复能力通过其前暴露于糖尿病Milieu”而受到损害
2. Erratum to “Implanted Muscle-Derived Stem Cells Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes, but Their Repair Capacity is Impaired by Their Prior Exposure to the Diabetic Milieu” [J] . The journal of sexual medicine . 2017,第1期

机译：错误的“植入肌肉衍生的干细胞改善2型糖尿病大鼠模型中的勃起功能障碍，但它们的修复能力通过其前暴露于糖尿病Milieu”而受到损害
3. Implanted Muscle-Derived Stem Cells Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes, but Their Repair Capacity Is Impaired by Their Prior Exposure to the Diabetic Milieu [J] . Kovanecz Istvan, Vernet Dolores, Masouminia Maryam, The journal of sexual medicine . 2016,第5期

机译：植入的肌肉衍生干细胞可改善2型糖尿病大鼠模型的勃起功能障碍，但其修复能力会因其先前暴露于糖尿病的环境而受损。
4. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodeling after myocardial infarction [C] . Yi Liu, Xiaoying Ye, Lina Mao, World biomaterials congress . 2012

机译：单性生殖胚胎干细胞的移植可改善心肌梗死后的心脏功能障碍和重塑
5. Molecular mechanisms of impaired tissue repair in thioacetamide-treated type 1 diabetic rats. [D] . Devi, Sachin S. 2006

机译：硫代乙酰胺治疗的1型糖尿病大鼠组织修复受损的分子机制。
6. IMPLANTED MUSCLE DERIVED STEM CELLS AMELIORATE ERECTILE DYSFUNCTION IN A RAT MODEL OF TYPE 2 DIABETES BUT THEIR REPAIR CAPACITY IS IMPAIRED BY THEIR PRIOR EXPOSURE TO THE DIABETIC MILIEU [O] . I Kovanecz, D Vernet, M Masouminia, -1

机译：植入的肌肉来源干细胞在2型糖尿病大鼠模型中改善了勃起功能障碍但其修复能力因其先前暴露于糖尿病环境而受损
7. Erratum to “Implanted Muscle-Derived Stem Cells Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes, but Their Repair Capacity is Impaired by Their Prior Exposure to the Diabetic Milieu” [O] . 2017

机译：错误“植入肌肉衍生的干细胞改善2型糖尿病大鼠模型中的勃起功能障碍，但它们的修复能力通过其前暴露于糖尿病Milieu”而受到损害

Implanted Muscle-Derived Stem Cells Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes, but Their Repair Capacity Is Impaired by Their Prior Exposure to the Diabetic Milieu

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