IMPLANTED MUSCLE DERIVED STEM CELLS AMELIORATE ERECTILE DYSFUNCTION IN A RAT MODEL OF TYPE 2 DIABETES BUT THEIR REPAIR CAPACITY IS IMPAIRED BY THEIR PRIOR EXPOSURE TO THE DIABETIC MILIEU

摘要

IntroductionMuscle derived stem cells (>MDSC) and other stem cells implanted into the penile corpora cavernosa ameliorate erectile dysfunction in type 1 diabetic (>T1D) rat models by replenishing the lost corporal smooth muscle cells (>SMC) and reducing fibrosis. However, no conclusive data on this question in T2/D/obesity models is available. >Aim. We studied whether: a) MDSC from T2D Obese Zucker (OZ) rats at an early stage of diabetes (>ED-SC), counteract corporal veno-occlusive dysfunction (>CVOD) and corporal SMC loss/lipofibrosis when implanted in the OZ rats at a late stage of diabetes; b) MDSC from these late diabetes OZ rats (>LD-SC) differ from ED-SC in their gene transcriptional phenotype and repair capacity.