Synthesis of 3-Aryl-8-oxo-5,6,7,8-tetrahydroindolizines via a Palladium-CatalyzedArylation and Heteroarylation

Stephanie Gracia; Clement Cazorla; Estelle Metay; Stephane Pellet-Rostaing; Marc Lemaire

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Synthesis of 3-Aryl-8-oxo-5,6,7,8-tetrahydroindolizines via a Palladium-CatalyzedArylation and Heteroarylation

机译：通过钯催化的芳基化和杂芳基化反应合成3-Aryl-8-oxo-5,6,7,8-四氢吲哚并

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A selective palladium-catalyzed arylation and heteroarylationof 8-oxo-5,6,7,8-tetrahydroindolizines has been developed.Mechanistic studies assume an electrophilic substitutionpathway for this transformation. This method provides an efficient one-step synthesis of 3-aryl-8-oxo-5,6,7,8-tetrahydro-indolizines.

机译：已经开发出了选择性钯催化的8-oxo-5,6,7,8-四氢吲哚并嗪的芳基化和杂芳基化反应。机理研究假设该转化具有亲电取代途径。该方法提供了3-芳基-8-氧代-5,6,7,8-四氢吲哚并嗪的有效一步合成。

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《The Journal of Organic Chemistry》 |2009年第8期|共4页
作者
Stephanie Gracia; Clement Cazorla; Estelle Metay; Stephane Pellet-Rostaing; Marc Lemaire;
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正文语种 eng
中图分类有机化学;
关键词
Synthesis; tetrahydroindolizines; Heteroarylation;

机译：合成;四氢吲哚嗪;杂芳基化;

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专利

1. Synthesis of 3-Aryl-8-oxo-5,6,7,8-tetrahydroindolizines via a Palladium-CatalyzedArylation and Heteroarylation [J] . Stephanie Gracia, Clement Cazorla, Estelle Metay, The Journal of Organic Chemistry . 2009,第8期

机译：通过钯催化的芳基化和杂芳基化反应合成3-Aryl-8-oxo-5,6,7,8-四氢吲哚并
2. Catalytic one-pot synthesis of 1-substituted 5,6,7,8-tetrahydroindolizine derivatives [J] . Biletzki T., Imhof W. European journal of organic chemistry . 2012,第33期

机译：1取代5,6,7,8-四氢吲哚嗪衍生物的催化一锅合成
3. Synthesis of 8-Oxo-3-acetylenic-5,6,7,8-tetrahydroindolizines via SonogashiraCoupling [J] . Stephanie Gracia, Estelle Metay, Stephane Pellet-Rostaing, Synlett . 2009,第16期

机译：SonogashiraCoupling合成8-Oxo-3-acetylenic-5,6,7,8-tetrahydroindolizinesnes
4. Direct Heteroarylation Polymerization of Low Bandgap Thiophene-Based Conjugated Polymers [C] . Jiyeon Yoon, Se Hyun Jang, Sang Yong Kim, Materials Research Society Meeting . 2014

机译：低带凝胶噻吩基缀合聚合物的直接杂芳基聚合
5. The Design and Synthesis of Novel Proteasome Inhibitors: Studies on the Synthesis of Nagelamide M and Analogs, the Synthesis of Rapamycin Based Proteasome Inhibitors, and the Synthesis of TCH Based Molecular Probes for Binding Site Determination. [D] . Giletto, Matthew Basil. 2017

机译：新型蛋白酶体抑制剂的设计与合成：Nagelamide M和类似物的合成，雷帕霉素基蛋白酶体抑制剂的合成以及TCH基分子探针的结合位点测定的研究。
6. Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines [O] . Rachel Grainger, Tom D. Heightman, Steven V. Ley, 2019

机译：通过反应性作图实现基于片段的药物发现中的合成：光氧化还原介导的环胺的交叉脱氢杂芳基化
7. Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines [O] . Rachel Grainger, Tom D. Heightman, Steven V. Ley, 2019

机译：通过反应性测绘能够在基于片段的药物发现中的合成：Choforedox介导的环状胺的介导的杂交杂芳基

Synthesis of 3-Aryl-8-oxo-5,6,7,8-tetrahydroindolizines via a Palladium-CatalyzedArylation and Heteroarylation

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