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DERIVATIVES OF 5,6,7,8-TETRAHYDROINDOLIZINE INHIBITING HSP90, COMPOSITIONS CONTAINING SAME, AND USE THEREOF
DERIVATIVES OF 5,6,7,8-TETRAHYDROINDOLIZINE INHIBITING HSP90, COMPOSITIONS CONTAINING SAME, AND USE THEREOF
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机译:抑制HSP90的5,6,7,8-四氢吲哚嗪衍生物,包含相同成分的组合物及其使用
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摘要
The invention relates to the novel materials of formula (I), Het and Het' being an aromatic or partially unsaturated, dihydro or tetrahydro, mono- or bicyclic heterocyclic compound having 5 to 11 members, containing 1 to 4 heteroatoms, selected from among N, O or S, optionally substituted by one or more identical or different radicals R1 or R'1 such as expressed below, X being NH-CO or CO-NH, R1 and/or R'1 belonging to the group consisting of H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, free carboxy or carboxy esterified by an alkyl radical, carboxamide, CO-NH(alkyl), CON(alkyl)2, NH-CO-alkyl, sulphonamide, NH-SO2-alkyl, S(O)2-NH-alkyl or S(O2)-N(alkyl)2, all the alkyl, alkoxy and alkylthio radicals in turn being optionally substituted by one or more identical or different radicals selected from among halogen, hydroxy, alkoxy, amino, alkylamino and dialkylamino, wherein said materials are in any isomer and salt form and used as drugs.
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