Enantio- and stereospecific syntheses of 15(R)-Me-PGD(2), a potent and selective DP2-receptor agonist

摘要

The first total synthesis of 15(R)-Me-PGD(2) 3 is reported. The synthesis is based on the enantioselective and stereospecific syntheses of synthon 17 and its attachment to the five-membered ring by a olefin cross metathesis reaction. This approach permits the introduction of a side chain with a predetermined stereogenic center into the prostanoid ring, resulting in the synthesis of 15R-methyl prostaglandin D-2 and allows rapid access to other prostanoids.