IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 activity via IL-15Rbeta / gamma, and hyperagonist (IL15Ralpha sushi-IL15) fusion protein

摘要

The present invention relates to the stimulation of the IL-15Rbeta/gamma signalling pathway, to thereby induce and/or stimulate the activation and/or proliferation of IL-15Rbeta/gamma-positive cells, such as NK and/or T cells. Appropriate compounds include compounds comprising at least one IL-15Rbeta/gamma binding entity, directly or indirectly linked by covalence to at least one polypeptide which contains the sushi domain of the extracellular region of an IL-15Ralpha.