Ligand Effects in the Synthesis of N-Heterocycles by Intramolecular Heck Reactions

摘要

Chemo- and regioselectivity of intramolecular Heck reactions are dependent on the type of ligand employed.Six- to eight-membered benzolactams are produced in good yields using PPh3 as ligand.In contrast,a biaryl coupling occurred preferentially under ligandless conditions to form a dihy-drophenanthridine product.