Construction of chiral tertiary alcohol stereocenters via the [2,3]- meisenheimer rearrangement: Enantioselective synthesis of the side-chain acids of homoharringtonine and harringtonine

摘要

For the first time, the [2,3]-Meisenheimer rearrangement has been developed into a general strategy for the construction of chiral tertiary alcohols. The effectiveness and practicality of this methodology are illustrated by the successful synthesis of (R)-20 and (R)-30, the side chain acids of homoharringtonine and harringtonine, respectively.