IB-01212,a New Cytotoxic Cyclodepsipeptide Isolated from the Marine Fungus Clonostachys sp.ESNA-A009

摘要

IB-01212,a new cytotoxic cyclodepsipeptide featuring C_2 symmetry,was isolated from the mycelium extract of Clonostachys sp.ESNA-A009.The amino acid sequence of the compound was determined by spectroscopy techniques.The absolute configuration of the amino acids was determined by a combination of the Marfey and menthol methods.The structure,which was confirmed by comparison of the analytical data for the natural product with a sample obtained by solid-phase peptide synthesis,was revealed to be a cyclic dimer formed by two chains of L-N,N-Me_2Leu-L-Ser-L-N-MeLeu-L-N-MePhe bound by the two esters formed between the carboxylic acid of the L-N-MePhe and the hydroxyl function of the L-Ser.IB-01212 is highly cytotoxic to different tumor cell lines.