The functional effect of soybean extract and isolated isoflavone on myocardial infarction and ventricular dysfunction. The soybean extract on myocardial infarction.

摘要

Background: Myocardial infarction is a public health problem. Functional food is an alternative treatment for cardiovascular diseases. Objective: The objective was to analyze the functional and anatomopathological post-myocardial-infarction effects of soybean extract (SE) and isoflavone (IF). Methods: Myocardial infarction was induced in adult Wistar rats. After 5 days, an echocardiogram was performed to determine heart rate (HR), ejection fraction (EF), systolic volume (LVESV) and diastolic volume (LVEDV). Animals with ventricular dysfunction (EF<45%) were selected for study. The animals were divided into three groups: control (n = 14), SE (n = 15) and IF (n = 12). The IF group received 120 mg/kg/day isolated IF, and the SE group received 12.52 g/day. After 30 days, a new echocardiogram was performed. A histological exam was carried out to determine the collagen. Activity of biochemical markers (arginase, lactate dehydrogenase (LDH) and malate dehydrogenase) was measured. Results: The animals of the control, IF and SE groups showed a reduction in EF after the infarction (P = .432, P = .017 and P = .320, respectively). An increase of LVESV and LVEDV was observed in all groups (P = .009, P = .001 and P = .140; and P = .003, P = .008 and P = .205, respectively). A reduction of HR was found in the SE group (P = .020). There was a greater activity of LDH in the SE group. A smaller quantity of mature collagen was found in the region proximal to the myocardial infarction in the SE group. Conclusion: A protective effect in the SE group was observed 30 days after the myocardial infarction