Use of caffeine for apnea of prematurity also has long-term neurodevelopmental benefits.

摘要

Question:Among preterm infants, does treatment with caffeine for apnea of prematurity have any long-term effects on neurodevelopment and growth?Design:Randomized controlled trial.Setting:Multiple centers in the United States, Canada, Europe, Australia, and Israel.Participants:2006 infants with birth, weights of 500 to 1250 g.Intervention:Infants received either caffeine or placebo until therapy for apnea of prematurity was no longer needed. Participants were followed to a corrected age of 18 to 21 months.