Amphotericin B deoxycholate and fluconazole are most effective treatments for invasive candidiasis in infants

摘要

Among infants with invasive candidiasis, which of the following treatment options is most effective at decreasing mortality: amphotericin B lipid products, amphotericin B deoxycholate, or fluconazole? Retrospective cohort study. 192 neonatal intensive care units (NICUs) in the US between 1997 and 2003. All infants <=120 days of age with positive blood, urine, or cerebrospinal fluid cultures for Candida species who received amphotericin B deoxycholate, fluconazole, amphotericin B lipid products, or combination therapy admitted to one of the participating NICUs.