INR elevation with maitake extract in combination with warfarin.

摘要

TO THE EDITOR: Maitake, Grifolajrondosa, is an edible mushroom with potential cancer benefits. Its potential benefits are thought to be associated with p-glucan (a protein-bound polysaccharide), which may stimulate macrophages, cytokines, and natural killer (NK) cells, leading to im-munostimulation. In vitro, maitake has demonstrated enhancement of murine hematopoietic stem cell proliferation and reduction in doxorubicin toxicity. Additionally, maitake inhibits lung metastasis by activating NK cells and increases murine tumor cell cytotoxicity in vitro.The safety of maitake use in combination with other medications is unknown. Warfarin has numerous drug interactions; however, an interaction between maitake and warfarin has not been previously described.