首页> 外文期刊>The Annals of occupational hygiene. >Investigation of PAH biomarkers in the urine of workers exposed to hot asphalt.
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Investigation of PAH biomarkers in the urine of workers exposed to hot asphalt.

机译:对暴露于热沥青的工人尿液中PAH生物标志物的调查。

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摘要

Airborne emissions from hot asphalt contain mixtures of polycyclic aromatic hydrocarbons (PAHs), including several carcinogens. We investigated urinary biomarkers of three PAHs, namely naphthalene (Nap), phenanthrene (Phe), and pyrene (Pyr) in 20 road-paving workers exposed to hot asphalt and in 6 road milling workers who were not using hot asphalt (reference group). Our analysis included baseline urine samples as well as postshift, bedtime, and morning samples collected over three consecutive days. We measured unmetabolized Nap (U-Nap) and Phe (U-Phe) as well as the monohydroxylated metabolites of Nap (OH-Nap), Phe (OH-Phe), and Pyr (OH-Pyr) in each urine sample. In baseline samples, no significant differences in biomarker levels were observed between pavers and millers, suggesting similar background exposures. In postshift, bedtime, and morning urine samples, the high pairwise correlations observed between levels of all biomarkers suggest common exposure sources. Among pavers, levels of all biomarkers were significantly elevated in postshift samples, indicating rapid uptake and elimination of PAHs following exposure to hot asphalt (biomarker levels were not elevated among millers). Results from linear mixed-effects models of levels of U-Nap, U-Phe, OH-Phe, and OH-Pyr across pavers showed significant effects of work assignments with roller operators having lower biomarker levels than the other workers. However, no work-related effect was observed for levels of OH-Nap, apparently due to the influence of cigarette smoking. Biological half-lives, estimated from regression coefficients for time among pavers, were 8 h for U-Phe, 10 h for U-Nap, 13 h for OH-Phe and OH-Pyr, and 26 h for OH-Nap. These results support the use of U-Nap, U-Phe, OH-Phe, and OH-Pyr, but probably not OH-Nap, as short-term biomarkers of exposure to PAHs emanating from hot asphalt.
机译:热沥青的空气中排放物包含多环芳烃(PAH)的混合物,其中包括几种致癌物。我们调查了20名暴露于热沥青的铺路工人和6名未使用热沥青的碾磨工人的三种PAH的尿生物标志物,即萘(Nap),菲(Phe)和pyr(Pyr)(参考组) 。我们的分析包括基线尿液样本,以及连续三天收集的轮班后,就寝时间和早晨样本。我们测量了每个尿液样本中未代谢的Nap(U-Nap)和Phe(U-Phe)以及Nap(OH-Nap),Phe(OH-Phe)和Pyr(OH-Pyr)的单羟基化代谢产物。在基准样品中,摊铺机和磨粉机之间未观察到生物标志物水平的显着差异,表明背景暴露相似。在轮班后,就寝时间和早晨尿液样本中,所有生物标志物水平之间观察到的高度成对相关性提示了常见的暴露源。在摊铺机中,班次后样品中所有生物标志物的水平均显着升高,表明暴露于热沥青后,PAHs的快速吸收和消除(制粉厂中生物标志物水平未升高)。跨摊铺机的U-Nap,U-Phe,OH-Phe和OH-Pyr的水平线性混合效应模型的结果表明,滚筒作业者的生物标志物水平低于其他工人,这对工作分配产生了重大影响。但是,显然由于吸烟的影响,没有观察到与OH-Nap水平有关的工作相关的影响。根据摊铺机之间时间的回归系数估算的生物半衰期,U-Phe为8 h,U-Nap为10 h,OH-Phe和OH-Pyr为13 h,OH-Nap为26 h。这些结果支持使用U-Nap,U-Phe,OH-Phe和OH-Pyr,但可能不使用OH-Nap,作为暴露于热沥青产生的PAH的短期生物标记。

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