Genetic polymorphism analysis of cytochrome P4502C19 in Chinese Uigur and Han populations

摘要

OBJECTIVE: To assess the genotype patterns of cytochrome P4502C19 in the Chinese Uigur and Han populations and compare them with other populations.METHODS: Ninety-six Uigur and 104 Han healthy, unrelated subjects (Uigur: 51 males, 45 females, aged from 23 to 30 years; Han: 53 males, 51 females, aged from 21 to 26 years) were genotyped for CYP2C19 by the PCR-RFLP technique to identify the wild-type (wt) gene and two mutations, CYP2C19_ml in exon5 and CYP2C19_m2inexon4.