Improvement of mucocutaneous involvement of immunoglobulin light chain amyloidosis after chemotherapy and hematopoietic stem cell transplantation for multiple myeloma

摘要

Dear Editor,Symptomatic light chain amyloid (AL) amyloidosis occurs in 12-15% of multiple myeloma patients, while up to 30% have clinically asymptomatic AL amyloidosis.1 Prognosis of multiple myeloma is markedly improved after introduction of autologous hematopoietic stem cell transplantation (ASCT) and novel anti-myeloma agents, such as bortezomib a.nd lenalidomide.2 However, it is still uncertain whether these treatments simultaneously improve AL deposition associated with myeloma. We herein reported a very rare and instructive case of AL amyloidosis associated with multiple myeloma where mucocutaneous involvement resolved after the achievement of complete remission (CR) of myeloma with these new treatment modalities, suggesting that this condition could resolve following targeted therapy against the underlying disease.A 68-year-old Japanese man complaining of a 5-month history of the numbness on the fingers and tongue swelling presented to our clinic. Past medical and family histories were unremarkable.