PHARMACEUTICAL COMPOSITION INCLUDING TAT-HOXB4H PROTEIN FOR ENHANCING MOBILIZATION OF HEMATOPOIETIC STEM CELL FROM BONE MARROW TO PERIPHERAL BLOOD, AND PHARMACEUTICAL COMPOSITION FOR IMPROVING RECOVERY TIME OF PATIENT HAVING UNDERGONE HEMATOPOIETIC STEM CELL TRANSPLANTATION, IRRADIATION, OR CHEMOTHERAPY

摘要

PPROBLEM TO BE SOLVED: To provide a pharmaceutical composition, including a TAT-HOXB4H protein, for enhancing mobilization of hematopoietic stem cells (HSC) from bone marrow to peripheral blood, and a pharmaceutical composition for improving the recovery time of a patient having undergone HSC transplantation, irradiation, or chemotherapy. PSOLUTION: The pharmaceutical composition, including the TAT-HOXB4H protein, for enhancing the mobilization of HSCs from bone marrow to peripheral blood is administered in an effective amount to a subject in need thereof, and allows the TAT-HOXB4H protein to increase the absolute number of HSCs in the bone marrow of the subject thereby enhancing the mobilization of HSCs to the peripheral blood of the subject. PCOPYRIGHT: (C)2011,JPO&INPIT