NC1101, a novel tetrahydropyrimidine-containing bleomycin analog from Streptomyces verticillus var. pingyangensis n. var.

摘要

The bleomycins (BLMs) are a family of glycopeptide anticancer antibiotics isolated from a fermentation broth of Streptomyces verticillus. Streptomyces verticillus var. pingyangensis n. var., isolated from a soil sample collected in Pingyang, Zhejiang Province, China, produces a complex of antitumor antibiotics belonging to the BLM family. We investigated it and discovered NCI 101, a new analog of BLM with a tetrahydropyrimidine ring in the terminal amine.