A novel potent cellcycle inhibitor dehydrophenylahistin-enzymatic synthesis and inhibitory activity toward Sea Urchin Embryo-

摘要

A novel dehydrogenated cyclic dipeptide named as dehydrophenylahistin (DELTAPLH) was effectively prepare dfrom a fungal metabolite(-)-phenylahistin by theenzymatic conversion catlayzed by the cell-free extract of Streptomyces albulus KO-23,an albonoursin-producing actinomycete.DELTAPLH exhibitedmore than 1,000 times as high potent inhibitory activity toward the first cleavage of sea urchin embryos as (-0-phenylahisitn which has been reported to be a cell cycle inhibitor and more than 10,000 as high as albonoursin,indicating that DELTAPLH is a promising leading compound for anticancer drugs.