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首页> 外文期刊>The Journal of Antibiotics: An International Journal >A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6.
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A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6.

机译:一种新的versipelostatin类似物,versipelostatin F,其分离自verseptellices versipellis 4083-SVS6。

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摘要

A novel versipelostatin (1) analogue, versipelostatin F (2) was isolated from Streptomyces versipellis 4083-SVS6. The structure of 2 was determined by the analyses of the spectroscopic data. Compound 2 inhibited the expression of GRP78 induced by 2-deoxyglucose with an IC(50) value of 0.3 muM, which is 10-times more potent compared with that of 1.
机译:一个新的versipelostatin(1)类似物,versipelostatin F(2)分离自versipellis versipellis 4083-SVS6。通过光谱数据分析确定2的结构。化合物2抑制了2-脱氧葡萄糖诱导的GRP78的表达,IC(50)值为0.3μM,比1的效力高10倍。

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