Bafilomycins N and O, novel cytotoxic bafilomycin analogues produced by Streptomyces sp GIC10-1 isolated from marine sponge Theonella sp.

摘要

Two novel 16-membered tetraene marcolides, bafilomycins N (1) and 0 (2), along with two known analogues, JBIR-100 (3) and bafilomycin K (4) were produced from isolate GIC10-1, a Streptomyces sp. strain that was originally cloned from bacterial communities associated with marine sponge Theonella sp. The structures of new bafilomycins 1 and 2 were established by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Compounds 1 and 2 were proven to be the first 14-methylbafilomycins to be isolated. Cytotoxicity of these compounds toward various cancer cell lines also is described. (C) 2017 Elsevier Ltd. All rights reserved.