Association of thromboxane A1 synthase (TBXAS1) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs

摘要

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs all over the world and represent the second most frequent cause of drug-induced hypersensitivity reactions (0.5% to 1.9% of the general population). In some circumstances an underlying disease, such as chronic urticaria or bronchial asthma, accompanies the clinical expression of this hypersensitivity. According to the pattern of reactivity among different NSAIDs, these reactions can be classified into cross-reactive or multiple hypersensitivity (MR), with cross-reactivity among different nonstructurally related NSAIDs, and selective (SR), in which a unique specific NSAID is the culprit drug.